| Customization: | Available |
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| CAS No.: | / |
| Formula: | / |
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| Tranexamic acid Basic information | |
| Product Name: | Tranexamic acid |
| CAS: | 1197-18-8 |
| MF: | C8H15NO2 |
| MW: | 157.21 |
| EINECS: | 214-818-2 |
| Tranexamic acid Chemical Properties | |
| Melting point | >300 °C (lit.) |
| Boiling point | 281.88°C (rough estimate) |
| density | 1.0806 (rough estimate) |
| refractive index | 1.4186 (estimate) |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water and in glacial acetic acid, practically insoluble and in ethanol (96 per cent). |
| form | Crystalline Powder |
| pka | pKa 4.3 (Uncertain);10.6 (Uncertain) |
| color | White |
| Water Solubility | 1g/6ml |
| Merck | 149,569 |
| BRN | 2207452 |
| InChIKey | GYDJEQRTZSCIOI-LJGSYFOKSA-N |
| CAS DataBase Reference | 1197-18-8 |
|
Test Item |
Analysis Specification |
Result |
|
Description |
White crystalline powder
|
Conform |
|
Identification |
IR test
|
Conform |
|
PH |
7.0~8.0 |
7.4 |
|
Related substances Liquid chromatography
|
ImpurityA ≤0.1% ImpurityB≤0.2% Any other impurity≤0.1% All other impurity≤0.2%
≤0.005% ≤0.05% |
<0.1% <0.2% <0.1% <0.2%
|
|
Loss on drying |
≤0.5% |
0.3% |
|
Residue on ignition |
≤0.1% |
<.08% |
|
Heavy metals |
≤10ppm |
<10ppm |
|
Chlorides |
≤14ppm |
<140ppm |
|
Sulphated ash |
≤0.1% |
<0.1% |
|
Assay |
99.0%~101.0% |
99.76% |
|
Conclusion |
Complies to BP2007 |
|
High purity Tranexamic Acid
Molecular formula of Tranexamic Acid: C8H15NO2
CAS number 1197-18-8
Alias: trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Mainly used for acute or chronic, localized or systemic fibrinolysis caused by all kinds of bleeding. For secondary hyperfibrinolysis caused by disseminated intravascular coagulation, use with caution before heparinization. Its effect of removing black spots is about 50 times higher than vitamin C, and nearly 10 times that of fruit acid.
Application Aera:
Trauma: Tranexamic acid has been found to decrease the risk of death in people who have significant bleeding due to trauma. However, it may actually increase the risk of death due to bleeding if administered more than 3 hours after the injury.
Heart surgery: Tranexamic acid is commonly used in cardiac surgery, both with and without cardiopulmonary bypass. It replaces aprotinin.
Orthopedic surgery:Tranexamic acid is used in orthopedic surgery to reduce bloodloss. It is of proven value in clearing the field of surgery and reducing pre- and postoperative blood loss. Drain and number of transfusions are reduced.
Menstrual bleeding: Used as firstline nonhormonal treatment of dysfunctional uterine bleeding, and heavy bleeding associated with uterine fibroids. A recent study showed patients treated with tranexamic acid are more likely to develop thrombosis and necrosis in their fibroids, and may result in pain and fever.
Dentistry: Tranexamic acid is used in dentistry in the form of a 5% mouth rinse after extractions or surgery in patients with prolonged bleeding time, e.g. from acquired or inherited disorders.
Other usesIn obstetrics, tranexamic acid is used after delivery to reduce bleeding, often with syntocinon/oxytocin and fundal massage.
In hemophilia: Tranexamic acid is also useful in the treatment of bleeding as a second line treatment after factor VIII in patients (e.g. tooth extraction)
Whitening effect: Clinical studies for years have proved that tranexamic acid can dilute spot effectively and rapidly, which helps to demonstrate a perfect white and bright skin. The spot-removing effect of tranexamic acid is about 50 times over Vitamin C, and 10 times over AHA. The concentration limit of usage is 2%-3%, and in cosmetics the amount is around 0.5%.
Package:
High Purity HA Hyaluronic Acid Powder
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